Direct myelin imaging using a 3D double adiabatic inversion recovery prepared ultrashort echo time (3D DIR-UTE) cones sequence
Motivation: Many neurological disorders are characterized by myelin damage and loss. Robust long T2 suppression is of critical importance for accurate myelin quantification due to myelin's low proton densities. Goal(s): To develop a new UTE imaging approach that enables sufficient long T2 suppression for selective myelin imaging. Approach: A 3D DIR-UTE sequence was developed for selective myelin imaging on a 3T clinical scanner. The technical feasibility was tested by phantom and in vivo studies. Results: The long T2 signals were sufficiently suppressed with the DIR scheme. The myelin proton fraction in white matter regions quantified by the DIR-UTE was 5.42±0.35%. Impact: The long T2 signals were sufficiently suppressed with the DIR scheme. The myelin proton fraction in white matter regions quantified by the DIR-UTE was 5.42±0.35%.
Authors
- Yajun Ma (ORCID: https://orcid.org/0000-0003-0830-9232)
- Dina Moazamian (ORCID: https://orcid.org/0000-0002-8815-4535)
- Kenichiro Doi (ORCID: https://orcid.org/0000-0002-9742-850X)
- Qingbo Tang (ORCID: https://orcid.org/0000-0002-7995-504X)
- Jiang Du (ORCID: https://orcid.org/0000-0002-9203-2450)
- Eric Yao Chang (ORCID: https://orcid.org/0000-0003-3633-5630)
- Soo Hyun Shin (ORCID: https://orcid.org/0000-0003-1875-2908)
- Jiyo Athertya (ORCID: https://orcid.org/0000-0002-0866-1052)
- James Lo (ORCID: https://orcid.org/0000-0002-7351-0752)
- Arya Suprana (ORCID: https://orcid.org/0009-0009-7946-0360)
- Bhavsimran Singh Malhi
- María Asunción Martín Lou
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2034
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00