Performance of T2 mapping in the staging of Graves’ ophthalmopathy based on different region of interest selection methods

Motivation: T2 relaxation time (T2RT) of extraocular muscle (EOM) derived from T2 mapping has been reported to be useful for staging patients with Graves’ ophthalmopathy (GO). However, due to the particularity of orbital anatomy, various region of interest (ROI) selection methods have been used in the process of T2RT measurements in GO. Goal(s): This study aimed to evaluate the performance of T2 mapping based on different ROIs for staging GO. Approach: T2RT-mean and T2RT-max values of EOM on coronal T2 mapping were measured and analyzed. Results: Taking reproducibility and diagnostic performance into consideration, T2RT-mean was found to be an ideal biomarker for staging GO. Impact: Taking reproducibility and diagnostic performance into consideration, T2RT-mean of EOM derived from T2 mapping was found to be an ideal biomarker for staging GO compared to T2RT-max.