Assessment of Synthetic 3T Image Generator for Accurate CSF Volume Measurement in T1-w, T2-w, and FLAIR Sequences Compared to Low-Field Imaging

Motivation: Addressing limited access to high-field MRI systems, our study investigates whether a Synthetic 3T Image Generator can enhance low-field MRI to match high-field image quality, crucial for accurate cerebrospinal fluid (CSF) volume analysis. Goal(s): We aimed to validate the efficacy of the Synthetic 3T generator in improving CSF volume measurements on low-field MRI, in comparison to high-field T1-w, T2-w, and FLAIR sequences. Approach: A cGAN was employed to enhance 64mT MRI data to synthetic 3T images, for evaluation in comparison to high-field MRIs. Results: The synthetic 3T images demonstrated significant improvements in CSF volume estimation across all sequences when compared to low-field images. Impact: The synthetic 3T MRI enhancements could advance neuroimaging in resource-limited settings, improve diagnostic precision for brain injuries and potentially broaden the application of neurological and psychiatric patient care worldwide and expand neuroimaging research opportunities.