Amide Proton Transfer Imaging Has added Value for Predicting Extraprostatic Extension in Prostate Cancer Patients

Motivation: Multi-parametric MRI is the most favorable imaging technique for local staging of PCa. Creating a combined model using these parameters would be desirable to improve the assessment of EPE. Goal(s): To verify the diagnostic efficiency of tumor size, LCC, ADC, APT, and their combined models for predicting EPE. Approach: The difference of tumor size, LCC, ADC and APT value between groups were compared. The ROC analysis was used for EPE prediction. Results: APT, ADC, tumor size and the LCC were independent predictors of EPE. The AUC of model III (APT +ADC+LCC+tumor size) were 0.869. Impact: These findings hold crucial clinical significance in the selection of appropriate therapeutic strategies for clinical cases of prostate cancer.