Differentiation of breast cancer subtypes using amide proton transfer-weighted imaging and DWI: the correlation with biological status

Motivation: APTWI and DWI had still some controversies between their parameters and some biological status. Goal(s): To assess the value of amide proton transfer-weighted imaging (APTWI) and diffusion weighted imaging (DWI) in differentiating biological subtypes and predicting the biological status of breast tumors. Approach: The Kruskal-Wallis H test and Post-hoc pairwise comparison, Pearson's correlation analysis. Independent samples t-test. Receiver operating characteristic (ROC) analysis. Results: MTRasym (3.5 ppm) was higher in breast tumours that were TN, ER-, PR-, and high-Ki-67. Compared to DWI, APTWI is more useful in predicting the biological status of breast cancers. Impact: Compared to DWI, APTWI is more useful in predicting the biological status of breast cancers.