Altered blood pulsatility & small vessel disease marker associations in obstructive sleep apnoea post-continuous positive airway pressure
Motivation: Sleep affects vascular health and brain waste clearance. Sleep disorders, including obstructive sleep apnoea (OSA), are associated with higher small vessel disease (SVD) burden increasing stroke/dementia risk. OSA treatment relies on continuous positive airway pressure (CPAP). Goal(s): We aimed to assess the effect of CPAP on MRI-based blood pulsatility index (PI) measures and associations with SVD burden. Approach: We assessed arterial/venous PI using phase-contrast MRI in patients with moderate/severe OSA before and after 4 months CPAP. Results: Arterial PI tended lower post-CPAP, consistent with better vascular health. Post-CPAP patients with higher venous PI had less severe basal ganglia perivascular space burden. Impact: Few studies have investigated MRI-based blood pulsatility index (PI) in obstructive sleep apnoea (OSA). We found effective treatment may improve brain vascular health, altering blood PI. Higher venous PI post-treatment may link to brain waste clearance, but requires further study.
Authors
- Andrew Lim (ORCID: https://orcid.org/0000-0003-2179-1553)
- Rosa Sommer
- Joanna Marguerite Wardlaw (ORCID: https://orcid.org/0000-0002-9812-6642)
- Rosalind Brown (ORCID: https://orcid.org/0000-0002-7688-4864)
- Renata L. Riha (ORCID: https://orcid.org/0000-0001-8983-9985)
- Fergus Doubal (ORCID: https://orcid.org/0000-0002-2769-3148)
- Bradley J. MacIntosh (ORCID: https://orcid.org/0000-0001-7300-2355)
- I. Howard Marshall (ORCID: https://orcid.org/0000-0001-7778-4331)
- Lucia Ballerini (ORCID: https://orcid.org/0000-0002-1956-4012)
- Michael J. Thrippleton (ORCID: https://orcid.org/0000-0001-7858-9917)
- Sandra E. Black (ORCID: https://orcid.org/0000-0001-7093-8289)
- José Bernal (ORCID: https://orcid.org/0000-0003-3167-5134)
- Francesca M. Chappell (ORCID: https://orcid.org/0000-0002-7742-1757)
- Elizabeth A. Hill (ORCID: https://orcid.org/0000-0002-9290-9734)
- Dany Jaime Garcia
- Alasdair G. Morgan (ORCID: https://orcid.org/0000-0001-9470-740X)
- Michael Stringer (ORCID: https://orcid.org/0000-0002-3811-4439)
- Roberto Duarte Coello (ORCID: https://orcid.org/0000-0003-2952-2163)
- Will Hewins
- Maria Valdés Hernández
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4920
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00