Investigating redox imbalance in first-episode schizophrenia using 7T functional MRS

Motivation: Redox imbalance in schizophrenia may help to explain the full range of observable schizophrenia symptoms. Goal(s): Our goal was to use a more appropriate tool to measure dynamic changes in neurometabolites in schizophrenia compared to traditional MRS techniques. Approach: We used functional MRS with a cognitive Stroop task to investigate glutathione dynamics as well as associated glutamate and glutamine dynamics. Results: Glutathione levels increased during task and stayed elevated for healthy subjects, but not for patients. Impact: By demonstrating abnormal anterior cingulate cortex glutathione response to short-term cognitive battery in first-episode schizophrenia, we offer novel support and added framework behind potential redox imbalances in schizophrenia and their utility in managing symptom treatment.