Spinal cord atrophy in aging and across different neurological diseases

Motivation: Determining the clinical significance of spinal cord changes across various neurological diseases. Goal(s): Determining the clinical significance of spinal cord changes across various neurological diseases. Approach: We compared the spinal cord changes across various neurological diseases, followed by analyzing the correlation of spinal cord atrophy with regional brain atrophy and corresponding clinical variables. Results: The spinal cord atrophy happens with aging and is aggravated in neurological diseases, which partly reflects cognitive conditions and physical disability. Impact: Identifying disease-specific patterns of spinal cord atrophy somehow helps in differential diagnosis and MUCCA could be serve as a MRI marker for cognitive impairment and/or physical disability.