Quantitative Susceptibility Mapping and Non-contrast Spin-labeling for CSF Outflow: A Dual Biomarker Approach for Neurodegenerative disease

Motivation: Recognizing the crucial role of iron accumulation and CSF clearance in neurodegenerative diseases, this study aimed to address gaps in measuring these factors simultaneously, which may enhance our understanding of neurodegenerative diseases. Goal(s): To employ a multiparametric approach integrating Quantitative Susceptibility Mapping (QSM) with non-contrast CSF outflow measurements in a single study. Approach: Utilize QSM and Time-SLIP techniques on a small cohort to measure and correlate iron levels in the hippocampus and CSF outflow dynamics. Results: We observed a correlation between iron deposition and age, though no significant age-related changes in CSF outflow were detected, underscoring the need for larger-scale studies. Impact: This study offers researchers a new perspective on the relationship between iron accumulation CSF dynamics and aging, potentially opening pathways for deeper investigation into the mechanisms of neurodegenerative diseases.