Metabolic story of functional connectivity in Parkinson’s Disease- A multimodal imaging perspective.

Motivation: Cortical regions are consequential in non-invasive brain stimulation studies in Parkinson’s Disease. It is important to investigate the cortical connectivity and understand the status of cortical networks with respect to the metabolic profile in PD. Goal(s): This study explored the metabolic profile (using 1H-magnetic resonance spectroscopy-MRS) and functional connectivity (resting state functional MRI). Approach: Resting state functional MRI (with 360 dynamics), 3D T1, single voxel 1H-MRS (in bilateral primary motor areas) were assessed in PD and controls. Results: Perturbations in cortico-cortical networks with increased choline metabolites signify loss in neural integrity. Impact: This study explores the cortical connectivity correlates with neural biochemistry. PD related changes in the cortical connectivity could be due to loss in neural integrity in primary motor area. Multimodal studies could lay a groundwork for brain stimulation studies.