PDFF diagnoses MASH in patients with severe obesity but without known liver disease
Motivation: To address the pressing need for non-invasive diagnosis of metabolic dysfunction-associated steatohepatitis (MASH). Goal(s): To evaluate the potential of proton-density fat-fraction (PDFF), corrected T1 (cT1), liver enzymes, and fibrosis scores to assist in the diagnosis of MASH. Approach: The study included study participants with obesity and at risk for MASH, undergoing bariatric surgery with intraoperative liver biopsy. Potential predictors and predictor combinations were evaluated as classifiers for MASH and steatosis. Results: PDFF distinguished MASH from non-MASH (AUC=0.85; 95%CI 0.79-0.91, p<0.0001). A cutoff of PDFF≥13.9% detected MASH with 90% specificity and 59% sensitivity. Neither cT1, liver enzymes, nor fibrosis scores significantly improved diagnostic performance. Impact: Our results suggest that PDFF alone may be sufficient for non-invasive detection of metabolic dysfunction-associated steatohepatitis (MASH). This novel use case for an established method has the potential to transform the diagnostic approach to MASH which currently necessitates invasive biopsy.
Authors
- Thekla Oechtering (ORCID: https://orcid.org/0000-0002-1931-1912)
- Eduardo Grunvald (ORCID: https://orcid.org/0000-0001-9332-7069)
- Claude B. Sirlin (ORCID: https://orcid.org/0000-0002-6639-9072)
- Gavin Hamilton (ORCID: https://orcid.org/0000-0001-9302-5546)
- Garth R. Jacobsen
- Anne O. Lidor (ORCID: https://orcid.org/0000-0002-9911-3114)
- Scott B. Reeder (ORCID: https://orcid.org/0000-0003-4728-8171)
- Daiki Tamada (ORCID: https://orcid.org/0000-0003-3615-459X)
- Yesenia Covarrubias
- Michael S. Middleton (ORCID: https://orcid.org/0000-0002-4247-1287)
- Lael Ceriani (ORCID: https://orcid.org/0000-0003-4427-4161)
- Rashmi Agni (ORCID: https://orcid.org/0000-0001-7803-4647)
- Luke M. Funk (ORCID: https://orcid.org/0000-0003-4475-304X)
- Danielle Batakis
- James R. Goodman (ORCID: https://orcid.org/0000-0001-9486-9898)
- Tanya Wolfson
- Nikolaos Panagiotopoulos (ORCID: https://orcid.org/0000-0002-0670-2754)
- David Harris (ORCID: https://orcid.org/0000-0003-4995-5126)
- Santiago Horgan
- Ryan Sappenfield
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4746
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.39