Aplastic Anemia in the Adults: Capability of Proton Density Fat Fraction Quantification for Hematopoietic Ability Assessment and Diagnosis

Motivation: PDFF quantification (PD-FFQ) with 6-point Dixon technique has a potential to assess hematopoietic ability assessment and diagnosis of aplastic anemia in adults. Goal(s): The goal was to determine the capability of PD-FFQ with 6-point Dixon technique for diagnosis of aplastic anemia in adults. Approach: Gender and age matched aplastic anemia patients and adults without aplastic anemia examined lumber MRI with PD-FFQ, and %CV and SD for vertebral bone marrow fat fraction were assessed and tested for differentiating two groups. Results: When applied feasible threshold value, specificity of %CV was significantly higher than that of SD (p=0.03). Impact: Proton density fat fraction quantification (PD-FFQ) with 6-point Dixon technique has a potential for hematopoietic ability assessment and diagnosis of aplastic anemia in adults.