T1 Mapping and Extracellular Volume Fraction in Patients with Suspected Acute Myocarditis: A Prognosis Study

Motivation: The prognostic value of T1 mapping and extracellular volume fraction (ECV) in acute myocarditis has not yet been supported by high-quality, evidence-based medicine. Goal(s): To investigate the prognostic value of T1 mapping and ECV in patients with acute suspected myocarditis. Approach: Patients meeting the recommended clinical criteria for suspected myocarditis were enrolled. The potential value for predicting MACE was explored using Cox proportional hazards models. Results: Patients with MACE showed higher global native T1 and ECV z scores and were more likely to have tissue changes in interventricular septum. Quantitative mapping parameters have incremental prognostic value beyond clinical variables and conventional CMR parameters. Impact: Our study reveals the prognostic predictive ability of native T1 and ECV in myocarditis. The application of mapping techniques will further contribute to the understanding of the pathophysiology of heart disease and will guide the development of effective therapeutic approaches.