Revealing abnormal brain motion in patients with neurodegenerative diseases using 3D quantitative-amplified MRI - A preliminary study

Motivation: 3D q-aMRI is a method for visualizing and quantifying the pulsatile brain sub-voxel displacement field. Here, we explore the potential of pulsatile brain motion as a biomarker for classification of common neurodegenerative diseases Goal(s): To explore the ability of 3D q-aMRI to detect abnormal brain motion in patients with common neurodegenerative diseasesApproach: The 3D q-aMRI outputs in 15 patients with different neurodegenerative diseases such mild cognitive impairment (MCI) due to Alzheimer's disease (AD), lewy body dementia (LBD), dementia due to AD were evaluated, and compared with healthy controls. Results: 3D q-aMRI revealed abnormal motion in patients with neurodegenerative diseases. Impact: 3D quantitative-amplified MRI is a pulsatile brain motion visualization and quantification method. Exploring pulsatile brain motion as a potential biomarker for neurodegenerative diseases classification is of great importance. 3D q-aMRI revealed abnormal pulsatile brain motion in patients with neurodegenerative diseases.