Interleaved HYDROPS: towards motion robust imaging of endolymphatic hydrops after intravenous administration of gadolinium

Motivation: HYDROS is useful method for detection of endolymphatic hydrops in patients with Meniere’s disease, but it has a potential risk for motion of patients during the acquisition because of its long scan time, resulting in misalignments of subtraction images. Goal(s): To develop a new sequence, called interleaved HYDROPS, which acquires PPI and PEI images with an interleaved manner in one single scan. Approach: We developed the interleaved 3D IR-prepared TSE with variable inversion delays. Interleaved HYDROPS were compared with conventional HYDROPS for image quality, particularly in the motion simulated situation. Results: Initial findings indicated good feasibility of interleaved HYDROPS, encouraging further clinical evaluation. Impact: Interleaved HYDROPS could provide PPI and PEI images with minimized motion effects during scan, compared with conventional separately acquired sequence. It holds promise for increasing robustness for motion-induced subtraction errors, but further studies are warranted to confirm its full potential.