Quantifying liver fibrosis via diamagnetic susceptibility sources using MRI: An ex-vivo feasibility study.
Motivation: Liver biopsy, traditionally regarded as the benchmark for liver fibrosis staging, is an invasive procedure that may cause infection and bleeding. Goal(s): To develop a non-invasive method to evaluate liver fibrosis using MRI. Approach: Diamagnetic sources are separated from paramagnetic sources using a biophysical model and multi echo gradient echo data. The value of the diamagnetic sources can be used to quantify the amount of accumulation of collagen due to liver fibrosis. Results: Significant differences in liver negative susceptibility were observed between lower stage, medium stage and higher stage of fibrosis. Impact: Multi-echo gradient echo data may provide a way to non-invasively stage liver fibrosis.
Authors
- Gary M. Brittenham (ORCID: https://orcid.org/0000-0002-5667-7446)
- Yi Wang (ORCID: https://orcid.org/0000-0002-8726-402X)
- Martin R. Prince (ORCID: https://orcid.org/0000-0002-9883-0584)
- Anne K. Koehne de González
- Jinwei Zhang (ORCID: https://orcid.org/0000-0003-1992-4636)
- Thanh Nguyen (ORCID: https://orcid.org/0000-0002-8440-1594)
- Pascal Spincemaille (ORCID: https://orcid.org/0000-0002-8821-1341)
- Chao Li (ORCID: https://orcid.org/0000-0002-0587-7421)
- Jiahao Li (ORCID: https://orcid.org/0000-0002-4706-4808)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4629
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00