Assessment of Daily Variations of GABA Levels within the Parietal Lobe and Anterior Cingulate Gyrus Regions of Healthy Young Adults Based on MRS.
Motivation: The assessment of GABA and Glx levels within the brain with MEscher-Garwood Point RESolved Spectroscopy (MEGA-PRESS) has an important role in the diagnosis and treatment of neuropsychiatric disorders. Goal(s): We evaluate the daily fluctuations of GABA levels within the parietal lobe (PL) and anterior cingulate gyrus (ACC) regions. Approach: The GABA+, GABA+/Cr , Glx/Cr ,Glx were measured at six different time points throughout the day using MEGA-PRESS. Results: Significant variations in GABA+/Cr levels within the PL region, with the lowest point occurring at 9:00 and the highest peak occurring at 21:00 . The melatonin levels were positively correlated with GABA+/Cr within the ACC region. Impact: GABA changes in localized brain regions are strongly associated with many psychiatric disorders. The outcomes of this study could be used to guide the diagnosis and treatment of neuropsychiatric disorders.
Authors
- Peng Wu (ORCID: https://orcid.org/0000-0003-2193-7356)
- Yangyang Tian (ORCID: https://orcid.org/0009-0009-2715-7183)
- X. Y. Wu (ORCID: https://orcid.org/0000-0002-4054-8498)
- Y Ye (ORCID: https://orcid.org/0009-0005-5137-7574)
- Shuting Han (ORCID: https://orcid.org/0000-0001-7625-4232)
- Zhaomin Zhong
- Yonggang Li (ORCID: https://orcid.org/0000-0001-8974-3094)
- Han Wang (ORCID: https://orcid.org/0000-0003-2420-3147)
- Zifan Wei
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1918
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00