MRI tagging and feature tracking detect increased myocardial strain in a mouse model of hypertrophic cardiomyopathy

Motivation: To identify potential imaging markers for early detection of hypertrophic cardiomyopathy (HCM) . Goal(s): To evaluate mechanical dysfunction in HCM mice with different genotypes representing different disease stages. Approach: Myocardial circumferential strain, radial strain, longitudinal strain, and torsion were assessed using two distinct strain assessment methods: feature tracking and tagging MRI. Results: The results showed a significant reduction in myocardial strain in severe HCM, but an intriguing trend of slight elevation was observed before a decline in strain occurred in mild HCM, highlighting the potential value of these markers in the early detection of HCM. Impact: Myocardial contractile function is significantly reduced in hypertrophic cardiomyopathy (HCM). However, our study suggests the presence of a compensatory phase during disease progression. Early identification of myocardial contraction dysfunction is vital for prompt detection and treatment, ultimately improving patient outcomes.