Abnormal connectome of dorsal raphe in methamphetamine addiction: a resting-state fMRI study
Motivation: This study aims to investigate the role of the dorsal raphe nucleus (DRN) and the ventral tegmental area (VTA) in the mechanism of methamphetamine (MA) induced nerve injury. Goal(s): To further explore the neural mechanism of MA addiction. Approach: Analyze the functional connections, effect connections, and graph theory analysis between DRN and VTA with other brain regions. Results: MA-dependent patients showed enhanced FC between the DRN and multiple brain regions in the whole brain. Topological analysis showed that multiple topological attributes of the dorsal raphe nucleus were abnormal. Impact: Aberrations in the connecome of the dorsal raphe nucleus among individuals with methamphetamine dependence may provide novel insights into the neural mechanisms underpinning addiction to this substance
Authors
- Gaoyan Wang
- Pu‐Yeh Wu (ORCID: https://orcid.org/0000-0002-9216-025X)
- Huifen Liu (ORCID: https://orcid.org/0000-0003-2559-3466)
- Wenwen Shen (ORCID: https://orcid.org/0000-0001-6840-5707)
- Mingyu Zhang (ORCID: https://orcid.org/0000-0003-2581-9058)
- Ping Chen (ORCID: https://orcid.org/0000-0002-9940-4528)
- Yadi Li (ORCID: https://orcid.org/0000-0002-1553-7922)
- Shuyuan Wang (ORCID: https://orcid.org/0000-0002-1232-821X)
- Jie Wang (ORCID: https://orcid.org/0000-0003-2031-7227)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1737
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00