Vascular Involvement Associated with Hypertension in Trigeminal Neuralgia Patients

Motivation: Trigeminal neuralgia is characterized by vascular compression of the trigeminal nerve, while neurogenic hypertension results from vascular compression in the medulla oblongata. Goal(s): To investigate the pathogenesis of TN in conjunction with hypertension and identify the vessels responsible,Approach: we conducted a retrospective population-based study including 457 TN patients,Results: and found a significant link between neurovascular conflict and hypertension. Specifically, arteries near the root entry zone, such as the anterior inferior cerebellar artery, vertebrobasilar artery, and superior cerebellar artery, were more associated with hypertension, especially when pain localized in the V2,3 area. Conversely, the posterior inferior cerebellar artery displayed an opposing trend. Impact: Patients with TN combined with neurogenic hypertension are recommended to take microvascular decompression (MVD) operation, who have these conditions in our study, will show potential improvements in their hypertension.