Effect of LCModel basis set B0 frequency on MRS quantification

Motivation: The actual B0 resonance field of 3T scanners is different between the three major MR vendors. Goal(s): Here, we report the effect on metabolite quantification of using basis sets at different B0 fields than the B0 frequency of the measured in vivo MRS data. Approach: Basis sets were simulated at thirteen different B0 fields. Semi-LASER MRS data measured from the posterior cingulate cortex at 3T were fitted using LCModel. Results: Results show that biases in metabolite concentrations were within 1% when the basis set B0 frequencies were within ±0.5 MHz from the actual scanner frequency. Impact: A single sequence-specific basis set can be used to analyze harmonized spectroscopic data collected on clinical 3T scanners from different vendors that operate at different frequencies.