Diffusion-T2 relaxation correlation spectroscopic imaging at 3T versus 5T: in vivo human brain application

Motivation: Motivated by the promise of higher SNR and gradient performance at ultra-high magnetic fields (5T), we conducted in-vivo experiments of diffusion-relaxation correlation spectroscopic imaging (DR-CSI) to tap into its prospects at 5T. Goal(s): This study aims to assess the feasibility and performance of DR-CSI at 5T for brain tissue measurement and to explore its 5T applications compared to 3T. Approach: We have acquired two-dimensional diffusion-relaxation data and resolved the 2D spectra and spatial maps at both field strengths for comparative analysis. Results: Results at 5T showed clearer differentiation of brain tissues and improved sensitivity to deep brain nuclei. Impact: At 5T, diffusion-relaxation correlation spectroscopic imaging excels in estimating deep brain nuclei, promising for future applications in infarcts and neurodegenerative conditions.