Effect of Nicotinamide riboside supplementation on cerebral NAD+ levels in vivo
Motivation: To determine if acute nicotinamide riboside (NR) supplementation increases cerebral nicotinamide adenine dinucleotide (NAD+) levels in the human brain. Goal(s): To measure cerebral NAD+ levels before and after nicotinamide riboside supplementation using downfield 1HMRS at 7T MRI in ten healthy volunteers. Approach: First MR scan was performed in each healthy volunteer after overnight fasting to obtain baseline NAD+ levels. In the second scan on the following day, the same protocol was repeated, but with NR supplements administered orally 4 hours before the scan. Results: An increase in mean NAD+ concentration was observed with NR supplementation, compared to the baseline (0.458±0.053 vs 0.392±0.058mM; p<0.001). Impact: The preliminary results from this study show that oral NR supplementation increases NAD+ levels in brain and demonstrates the potential of downfield 1HMRS for noninvasive quantification of cerebral NAD+ and monitoring the effects of NR supplementation on cerebral NAD+ levels.
Authors
- Ravi Prakash Reddy Nanga (ORCID: https://orcid.org/0000-0002-3644-5656)
- Ravinder Reddy (ORCID: https://orcid.org/0000-0003-4580-2392)
- Joseph A. Baur (ORCID: https://orcid.org/0000-0001-8262-6549)
- Ryan Armbruster (ORCID: https://orcid.org/0000-0003-0469-8816)
- Walter R T Witschey (ORCID: https://orcid.org/0000-0003-1669-2120)
- Quy Cao (ORCID: https://orcid.org/0000-0002-6204-1305)
- John A. Detre (ORCID: https://orcid.org/0000-0002-8115-6343)
- Neil E. Wilson (ORCID: https://orcid.org/0009-0002-7766-2929)
- Paul S. Jacobs (ORCID: https://orcid.org/0000-0003-3566-4010)
- Corinde E. Wiers (ORCID: https://orcid.org/0000-0002-2934-8794)
- Fang Liu (ORCID: https://orcid.org/0000-0003-2922-4414)
- Mark Elliott (ORCID: https://orcid.org/0000-0002-5281-7245)
- Damodara Reddy
- Sophie Swago
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4373
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00