Clinical study on distinguishing Triple-Negative Breast Cancer from Non-Triple-Negative Breast Cancer using 3D-APT and DWI

Motivation: Triple-negative breast cancer (TNBC) is a highly malignant and prognostically challenging subtype of breast cancer often elusive in conventional MRI scans [1.4.5]. Three-Dimensional Amide Proton Transfer Imaging (3D-APT), a non-invasive molecular imaging technique, shows promise in improving TNBC diagnosis. Goal(s): This study aimed toinvestigate the diagnostic potential of 3D-APT, alone and in conjunction with diffusion-weighted imaging (DWI), in distinguishing TNBC from non-TNBC. Approach: Quantitative analysis and comparison of APTw and DWI were conducted. Results: Results revealed higher APTw and ADC values in TNBC compared to non-TNBC. Both APTw and DWI exhibit commendable diagnostic efficiency individually, while their combined application demonstrates superior discriminatory power. Impact: These findings provide essential insights for tailoring individualized treatment strategies and assessing prognosis in clinical practice.