Synthetic MRI for the quantitative Assessment of efficacy of Immunotherapy in nasopharyngeal carcinoma.

Motivation: Due to the internal heterogeneity of the nasopharyngeal carcinoma, conventional treatment fails to enhance the tumor microenvironment, ultimately leading to recurrence or metastasis. Goal(s): To investigate whether quantitative values derived from T1, T2, and PD maps can serve as an assessment index for combined immunotherapy with chemotherapy in patients with newly diagnosed locally advanced NPC. Approach: Synthetic MRI, non-invasive technique, can generate quantitative values for intrinsic tissue features. Results: The study indicate the potential of PD and T2 values in distinguishing between two treatment. A larger sample size is required to further validate the value of SyMRI in evaluating immunotherapy for NPC. Impact: Synthetic MRI can generate longitudinal relaxation time (T1), transverse relaxation time (T2), and proton density (PD).