The relationship of intracellular sodium fraction and pharmacokinetics in breast cancer
Motivation: Breast cancer MRI has high sensitivity but has an unmet need for increased specificity. Sodium MRI has the potential to improve tumor characterisation and thus treatments. Goal(s): To determine whether there is a relationship between tissue permeability by correlating intracellular sodium fraction with pharmacokinetic parameters. Approach: Conventional DCE-MRI parameters were acquired as well as intracellular sodium fraction maps (= inversion recovery sodium / total sodium concentration) in 17 breast cancer lesions (grade 1:n=3; grade 2: n=9; grade 3:n=7). Results: The fraction of intracellular sodium to total sodium concentration had significant correlations (p-values <0.11) with Ktrans and kep, and with cancer grade. Impact: Breast cancer imaging has an unmet need to differentiate ductal carcinoma from benign and invasive lesions. Sodium MRI can provide intra- and extra-cellular sodium measurements, which may improve lesion differentiation by using endogenous contrast.
Authors
- Otso Arponen (ORCID: https://orcid.org/0000-0002-8541-0126)
- Roido Manavaki (ORCID: https://orcid.org/0000-0002-4384-6626)
- William J. Brackenbury (ORCID: https://orcid.org/0000-0001-6882-3351)
- Gabrielle Baxter (ORCID: https://orcid.org/0000-0002-8242-1559)
- Fiona J. Gilbert (ORCID: https://orcid.org/0000-0002-0124-9962)
- Frank Riemer (ORCID: https://orcid.org/0000-0002-3805-5221)
- Jonathan R. Birchall (ORCID: https://orcid.org/0000-0003-3920-4038)
- Joshua Kaggie (ORCID: https://orcid.org/0000-0001-6706-3442)
- Andrew B. Gill (ORCID: https://orcid.org/0000-0002-9287-9563)
- Ramona Woitek (ORCID: https://orcid.org/0000-0002-9146-9159)
- Aneurin J. Kennerley (ORCID: https://orcid.org/0000-0002-7599-7461)
- Mary McLean
- Muzna Nanaa (ORCID: https://orcid.org/0000-0001-7884-456X)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1474
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00