Association of glymphatic system impairment with aging and cognitive decline in Parkinson's disease

Motivation: In this study,we aimed to investigate the activity of the glymphatic system in PD using DTI-ALPS method and to further explore the correlation patterns of DTI-ALPS indexes with aging and cognitive impairment. Goal(s): To explores the correlation between glymphatic system impairment and cognitive impairment. Approach: Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index offers a noninvasive alternative and the method has been validated well with standard glymphatic MRI. Results: Our study found that glymphatic system function was impaired in PD as reflected by DTI-ALPS. Glymphatic dysfunction may lead to cognitive impairment,which was affected by aging and disease state. Impact: Our study explores the correlation between glymphatic system impairment and cognitive impairment.This finding provides new perspectives on cognitive impairment in patients with PD and suggests potential strategies for treating cognitive impairment in such patients.