Asymmetric impairment of hippocampus in patients with type 2 diabetes mellitus related with cognitive function
Motivation: To explore the relationship between hippocampal perfusion asymmetry and hippocampal enlarged perivascular spaces (H-EPVS) and cognitive function in patients with T2DM. Goal(s): To explore the relationship between hippocampal perfusion asymmetry and H-EPVS and cognitive function in patients with T2DM. Approach: CBF in hippocampus,H-EPVS and cognitive function were compared between HCs and patients with T2DM .The relationship between CBF in hippocampus, H-EPVS counts and cognitive measurement was analyzed. Results: In patients with T2DM, hippocampal perfusion was reduced and H-EPVS counts were higher on the left side. Decreased right hippocampal perfusion and increased left H-EPVS count were associated with cognitive impairment in patients with T2DM . Impact: Asymmetric impairment of hippocampal in patients with T2DM , and the asymmetry may be caused by a variety of mechanisms and may contribute to cognitive impairment.
Authors
- Kai Ai (ORCID: https://orcid.org/0000-0002-7326-0706)
- Jie Gao (ORCID: https://orcid.org/0000-0002-4648-7956)
- Dongsheng Zhang (ORCID: https://orcid.org/0000-0001-9633-8521)
- Jing Li (ORCID: https://orcid.org/0000-0003-3499-742X)
- Xiaoling Zhang (ORCID: https://orcid.org/0000-0001-9200-8832)
- Min Tang (ORCID: https://orcid.org/0000-0002-3381-7207)
- Peng Wu (ORCID: https://orcid.org/0000-0003-0355-006X)
- Peichun Pan
- Xiaoyan Lei (ORCID: https://orcid.org/0009-0002-5138-2830)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4364
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00