Validation of mDixonQuant and IntelliSpace Portal for Liver Iron Estimation

Motivation: Simultaneous estimation of fat, water, and iron concentrations by MRI are now available on all three major MRI vendors, but the predicted liver iron concentration (LIC) values are sparsely validated. Goal(s): To cross validate LIC estimates generated by Philips mDixonQuant and IntelliSpace Portal (ISP) against LIC values measured by biopsy-validated, reference R2* and R2 methodsApproach: 51 subjects underwent MRI for clinical purposes, with collection of mDixonQuant, standard multiple-echo gradient echo, and Ferriscan R2 images. Results: R2* values generated by the default mDixonQuant and ISP packages yielded accurate LIC estimates using the Garbowski calibration for LIC < 25 mg/g. Impact: This work allows mDixonQuant and ISP to be used with confidence in the clinical setting to quantify liver siderosis in most subjects referred for iron quantification.