The effect of [6,6'-2H2]glucose dose on human brain deuterium metabolic imaging at 7T

Motivation: Deuterium metabolic imaging (DMI) is used to study metabolic processes, but the effect of varying substrate doses on DMI data in the brain is not yet knownGoal(s): Comparing different doses aims to reduce cost, while still achieving sufficient sensitivity for DMIApproach: Three healthy participants received different doses of [6,6'-2H2]glucose on two occasions and underwent dynamic 7T DMI scansResults: In 120-minutes after ingesting [6,6'-2H2]glucose , there is no clear difference in the signal of 2H-glucose/2H-Glx in the brain between the 0. 50-0.75g/kg doses. However, there was an earlier decrease in the signal when using the 0.25g/kg dose in one subject. Impact: We compared three different doses [6,6'-2H2]glucose for Deuterium Metabolic Imaging of the brain, at 7T. Metabolite signals were comparable for the 0.50g/kg and 0.75g/kg doses, making 0.50g/kg a potential cost-saving alternative for clinical translation.