3D Diffusion Image Acquisition with Motion Offsetting andNavigation-Dependent Segmentation (DIAMONDS)

Motivation: Investigate whether 1D navigator echo phase information can be used to correct residual phase errors in single thick-slab segmented 3D-DWI with first and second order motion-compensated diffusion encoding gradients. Goal(s): Perform high-resolution single thick-slab segmented 3D-DWI with full brain coverage. Approach: Extend a first and second order motion-compensated segmented 3D-DWI sequence with three orthogonal 1D navigators, which are utilized to correct for residual phase errors. Results: Correction of zeroth order phase shifts, which result from translation, demonstrated reduction of ghosting artifacts. First order phase terms, which arise from rotation, were also determined, but require a more complex correction strategy. Impact: Motion-compensated single thick-slab segmented 3D-DWI with orthogonal 1D navigators is a completely novel and promising approach for high resolution diffusion imaging with full brain coverage.