Weight loss predicts the modulation of dACC glutamate during inhibitory control that is specific to food-cues: Evidence from ¹H fMRS

Motivation: The neurobiological mechanisms involved in poor weight loss maintenance are not understood. Goal(s): Our goal was to investigate neurobiological differences in glutamate modulation across different motor/inhibitory control responses after completion of a clinical weight loss program. Approach: 1H fMRS was conducted in a pilot sample who had completed a clinical weight loss program. Results: The presence of food cues as the stimuli influenced the glutamate modulation during inhibitory control responses. Impact: With further investigation, our preliminary evidence of a food-cue specific difference in glutamate modulation may fuel better treatment plans to support more successful maintenance of weight loss.