Real-time hyperpolarized 13C-pyruvate CMRI imaging pipeline for monitoring of cardiotoxicity
Motivation: Real-time imaging protocol based on hyperpolarized 13C pyruvate to probe metabolic changes in patients undergoing standard-of-care chemotherapy for breast cancer, with cardiotoxic potential. Goal(s): An imaging protocol that results in high-quality reproducible B0 heart shimming. To implement an echo-shifted mDIXON acquisition with spatial-spectral excitation to detect pyruvate and its major byproducts. A processing pipeline for reconstruction of metabolic images. Approach: Single-shot EPI acquisitions with shifted echo times (n=6) were acquired following a SpSp excitation, as to generate signal for mDIXON / IDEAL reconstructed images of these metabolites. Results: We have established a real-time 13C-hyperpolarization and imaging protocol and reconstruction pipelineImpact: Noninvasive real-time metabolic imaging using hyperpolarized 13C may aid clinical evaluation of possible cardiac toxicity for breast cancer patients
Authors
- Zoltán Kovács (ORCID: https://orcid.org/0000-0003-0657-3419)
- Ivan Dimitrov (ORCID: https://orcid.org/0000-0003-2686-6884)
- Maximilian Füetterer (ORCID: https://orcid.org/0000-0002-7456-1180)
- Vlad Gabriel Zaha (ORCID: https://orcid.org/0000-0003-4878-891X)
- Sebastian Kozerke (ORCID: https://orcid.org/0000-0003-3725-8884)
- Jae Mo Park (ORCID: https://orcid.org/0000-0002-7404-6971)
- Aneela Afzal (ORCID: https://orcid.org/0000-0002-0073-8166)
- A Henning (ORCID: https://orcid.org/0000-0002-2267-4861)
- Crystal Harrison (ORCID: https://orcid.org/0000-0002-8884-2805)
- Craig R. Malloy (ORCID: https://orcid.org/0000-0001-5077-0642)
- Fatemeh Khashami
- Mai Huynh
- Emily Buchanan (ORCID: https://orcid.org/0000-0001-6335-3004)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/5151
- Primary Topic
- Electron Spin Resonance Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00