Gray matter morphological abnormities are constrained by normal structural covariance network in OCD

Motivation: Whether abnormal gray matter morphology is constrained by normal brain network architecture in in obsessive-compulsive disorder (OCD) remains unknown. Goal(s): We investigated the association between gray matter morphological abnormities and normal structural covariance network architecture. Approach: Ninety-eight first-episode and drag-naive patients with OCD and matched healthy controls (HCs) were included in this study. Results: Gray matter abnormities are constrained by structural connectome and provide new insights into the possible pathological progression in OCD. Impact: We investigated the association between gray matter morphological abnormities and normal structural covariance network architecture in OCD. We found that the structural abnormalities are constrained by structural covariance connectome of multiple disease epicenters in OCD.