Free-running, Ferumoxytol-Enhanced Cardiac High-Dynamic-Range QSM (HDR-QSM) for Motion-resolved Myocardial Blood Volume Quantification
Motivation: Myocardial Blood Volume (MBV) is an important factor in the progression of cardiac pathologies. Goal(s): We proposed to combine a motion-resolved cardiac high-dynamic-range quantitative susceptibility mapping (HDR-QSM) approach with ferumoxytol (an iron-based intravascular contrast agent) to accurately measure myocardial blood volume (MBV). Approach: HDR-QSM was prescribed in pigs with and without AMI after ferumoxytol administration to investigate the cyclic MBV changes and infarct-induced MBV redistribution in AMI. Results: Significant MBV difference was observed between systolic and diastolic phases between healthy and infarcted hearts. Impact: Ferumoxytol-enhanced cardiac QSM has the potential to accurately quantify motion resolved MBV in healthy and diseased hearts.
Authors
- Chia-Chi Yang (ORCID: https://orcid.org/0000-0003-0933-7067)
- Ghazal Yoosefian
- Xingmin Guan (ORCID: https://orcid.org/0000-0002-3698-1811)
- Xinheng Zhang (ORCID: https://orcid.org/0000-0002-6347-8066)
- Yuheng Huang (ORCID: https://orcid.org/0009-0000-2890-2442)
- Rohan Dharmakumar (ORCID: https://orcid.org/0000-0003-4120-4635)
- Archana Malagi (ORCID: https://orcid.org/0000-0002-2332-170X)
- Hui Han (ORCID: https://orcid.org/0000-0001-9320-3808)
- Xinqi Li (ORCID: https://orcid.org/0009-0006-6316-9497)
- Debiao Li (ORCID: https://orcid.org/0000-0001-8560-8231)
- Li-Ting Huang
- Anthony Christodoulou (ORCID: https://orcid.org/0000-0002-9334-8684)
- Hsin-Jung Yang
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1779
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00