Multi-contrast Multi-resolution UTE for Myelin Fraction Mapping
Motivation: The direct detection of myelin is not possible due to extremely short T2 of the myelin bilayer. Ultra-short T2* component can be calculated with ultra-short echo-time (UTE) sequences. Goal(s): To evaluate the performance of the multi-contrast multi-resolution 3D-UTE sequence (mcUTE) in myelin fraction estimation. Approach: Combining 1-1 binomial water-excitation pulses and zero-moment encoding in between, mcUTE enables simultaneous acquisition of quantitative and high-resolution water-excited structural images. Myelin fraction from mcUTE is compared to myelin water fraction method. Results: Myelin fraction values were comparable with literature, and consistent within the subjects. Impact: mcUTE can potentially be used as a single imaging modality for myelin fraction estimation since it produces both quantitative and a high resolution water-excited anatomical image data in 18mins with TE=20μs. Our results show the acquisition can be further accelerated.
Authors
- Uzay E. Emir (ORCID: https://orcid.org/0000-0001-5376-0431)
- Shuai Liu (ORCID: https://orcid.org/0009-0002-4404-661X)
- Serhat İlbey (ORCID: https://orcid.org/0000-0002-3574-4320)
- Michael Bock (ORCID: https://orcid.org/0000-0001-9720-3506)
- Marco Reisert (ORCID: https://orcid.org/0000-0003-2742-1940)
- Ali Çağlar Özen (ORCID: https://orcid.org/0000-0003-3536-0826)
- Alexander Rau (ORCID: https://orcid.org/0000-0001-5881-6043)
- Nan Yin (ORCID: https://orcid.org/0000-0002-3481-7102)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4588
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00