Simultaneous Multi-Region Detection of GABA+ and Glx using 3D Spatially Resolved SLOW-editing and EPSI-readout at 7T

Motivation: Robust B0 and B1+ detection of GABA+ and Glx in 3D or whole brain MRSI using spectral editing is challenging at 7T. Goal(s): To simultaneously detect GABA+ and Glx in multi-regions and generate 3D maps using SLOW-editing for human brain at 7T. Approach: SLOW-EPSI was performed on 5 healthy volunteers. Results: Our method is robust to [-0.3 ppm, +0.3 ppm] B0 and [40%, 250%] B1+ for GABA+/Glx editing. 9-minute acquisition is sufficient for any arbitrarily shaped volume quantification. 18-27 minutes acquisition is sufficient for 3D mapping of GABA+. 9-18 minutes acquisition is sufficient for 3D mapping of Glx. Impact: Our work presents a large 3D or whole-brain MRSI tool for GABA+ and Glx quantification and mapping at 7T, which allows clinicians to examine changes in GABA+ and Glx in the brain for any arbitrarily shaped volume.