The role of glymphatic function and CSF circulation in patients with glioma
Motivation: Limited research has been performed on the role of CSF circulation in the glymphatic transport in patients with glioma. Goal(s): To evaluate the relationship between CSF circulation disturbance and glymphatic dysfunction in different glioma subtypes. Approach: A novel measure of glymphatic function (ALPS index) was quantified and compared among 100 patients with different genetic subtypes and associated with CSF circulation related factors and tumor volume. Results: We found that lower ALPS index in the tumor hemisphere was found in IDH-wildtype glioblastomas and with increasing grade in IDH-mutant gliomas. CSF circulation related factors were correlated with disruptions in glymphatic function. Impact: Our promising results provide a novel insight of glymphatic dysfunction in patients with glioma.
Authors
- Susan Chang (ORCID: https://orcid.org/0000-0003-3521-364X)
- Janine Lupo (ORCID: https://orcid.org/0000-0002-0051-6387)
- Angela Jakary (ORCID: https://orcid.org/0000-0002-2759-684X)
- Tracy Luks (ORCID: https://orcid.org/0000-0003-0994-9960)
- Duan Xu (ORCID: https://orcid.org/0000-0003-0550-4235)
- Reza Eghbali (ORCID: https://orcid.org/0000-0002-4436-2594)
- Oluwaseun Adegbite
- Xiaodan Liu (ORCID: https://orcid.org/0000-0002-3387-2177)
- Villanueva-Meyer Javier
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4921
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00