Quantitative, time-efficient viability CMR with delayed phase dynamic contrast-enhanced (dDCE) MRI
Motivation: Late gadolinium enhancement (LGE) CMR‘s wider clinical adoption is hindered by its prolonged wait time and imaging protocol dependence. Goal(s): Develop a delayed dynamic contrast enhancement (dDCE) model to shorten the LGE wait time and provide a quantitative characterization of the myocardium contrast washout process. Approach: Dynamic T1 maps were acquired in the contrast washout period in dogs with myocardial infarctions. dDCE maps and synthesized LGE images were derived from data collected within 5-minute post-contrast injection. Results: The 5-minute dDCE maps provide physiologically reasonable measurements and comparable myocardial viability assessment ability to standard LGE images. Impact: The shortened LGE wait time from the quantitative dDCE maps may benefit patients unable to tolerate long CMR examination time and open new dimensions for quantitative myocardium viability assessment.
Authors
- Yen‐Wen Liu (ORCID: https://orcid.org/0000-0003-4662-628X)
- Alan C. Kwan (ORCID: https://orcid.org/0000-0002-4393-1011)
- Ghazal Yoosefian
- Xinqi Li (ORCID: https://orcid.org/0009-0002-4799-8333)
- Xinheng Zhang (ORCID: https://orcid.org/0000-0002-6347-8066)
- Yuheng Huang (ORCID: https://orcid.org/0009-0000-2890-2442)
- Xun Guan (ORCID: https://orcid.org/0000-0001-5045-6004)
- Rohan Dharmakumar (ORCID: https://orcid.org/0000-0003-4120-4635)
- Archana Malagi (ORCID: https://orcid.org/0000-0002-2332-170X)
- Hsin‐Jung Yang (ORCID: https://orcid.org/0000-0001-9379-5495)
- Li-Ting Huang
- Anthony Christodoulou (ORCID: https://orcid.org/0000-0002-9334-8684)
- Hui Han
- Debiao Li
- Hao Ho
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1505
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00