Alterations in the lateralization of the infant brain with white matter injury

Motivation: To investigation of cerebral asymmetry in full-term newborns and alterations in the lateralization of the infant brain with white matter injuryGoal(s): To explore brain volume laterality in normal full-term newborns and the effect of infant with WMI on laterality. Approach: Calculated asymmetry index, used non-parametrically to test the significant, compared the difference of AI with the WMI group. Results: The distribution of lateralized significance in brain regions between groups was near the same. Significant differences were found between the groups in the hippocampus, amygdala, superior temporal gyrus middle part GM, occipital lobe GM, superior temporal gyrus middle part WM, and caudate nucleus. Impact: WMI can cause localized lateralized changes in brain regions, which may be associated with future adverse developmental outcomes and might be a biomarker for predicting prospective developmental outcomes of WMI.