Imaging phenotypes-based quantification of intratumor heterogeneity using APTw for predicting progression in lower grade glioma.

Motivation: In the setting of lower grade glioma follow heterogeneity of prognosis, it is currently necessitating risk stratification. Goal(s): To determine the predictive ability of amide proton transfer-weighted (APTw) imaging phenotypes in lower grade glioma. Approach: The ability of APTw phenotypes to PFS was evaluated using biomarker threshold model, The predictive model was trained on 67%, and tested on the remainder. Results: APTw imaging phenotypes can predict the progression free survival of lower grade gliomas. Impact: The independent and additional prognostic value of imaging phenotypes in APTw suggests that APTw imaging phenotypes can provide a noninvasive characterization of tumor cellular, proliferation and invasiveness to augment personalized prognosis and treatment in patients with lower grade glioma.