Different Tracer Kinetic Models in predicting key molecular marker in adult diffuse Gliomas

Motivation: IDH, P53 and CDKN2A/2B are key molecular markers for adult diffuse gliomas. Goal(s): This study aimed to compare values of conventional and advanced tracer kinetic models based on dynamic contrast enhanced (DCE)-MRI in predicting IDH, P53 and CDKN2A/B status in glioma patinets. Approach: Patients diagnosed as adult diffuse gliomas were examined using dynamic contrast-enhanced MRI. Imaging data were analyzed using tracer kinetic models. Results: Extofts model attained best performance in predicting IDH mutation.ATH model attained best performance in predicting P53 mutation. DP model attained best performance in predicting CDKN2A/B homozygous deletion. Impact: Different Tracer Kinetic Models have illustrated excellent performance in predicting different molecular markers in glioma patients.