Multiparametric MRI based assessment of kidney injury in a mouse model of ischemia reperfusion injury

Motivation: Assessment of kidney health is paramount for early diagnosis of impairment and subsequent methods of intervention. Goal(s): This study enhances our understanding of kidney pathophysiology using multiparametric MRI analysisApproach: Parsimonious pharmacokinetic modelling of the DCE-MRI data along with ASL and DWI was used to assess longitudinal changes in glomerular filtration rate (GFR) and kidney function in a mouse model of ischemia reperfusion injury. Results: Findings suggest that Renal Blood Flow (RBF), parsimonious filtration quotient (Ft), GFR, kidney volume, and Apparent Diffusion Coefficient (ADC) are important in comprehending the renal effects induced by ischemia reperfusion injury. Impact: This study provides an improved understanding of renal pathophysiology and underscores the value of multi-parametric MR imaging for assessing early changes in kidney function due to IRI, which may aid in early diagnosis of kidney injury and monitoring treatment response.