Evaluation of Therapeutic Effect of Myocardial Infarction Patch Using Cardiac Magnetic Resonance Imaging
Motivation: Evaluation of therapeutic effect of myocardial infarction（MI） patch using cardiac magnetic resonance （CMR） imagingGoal(s): Cooperation between medicine and polymer scienceApproach: We made a pig model of MI. The MI pigs in the patch group attached the patch to the epicardial side, while the MI pigs in the control group were not treated. We performed CMR imaging before operation, 2 weeks and 8 weeks after modeling. Finally, the heart was taken for pathological verification. Results: Compared with the control group, the patch group pig had thicker ventricular wall, better cardiac function and smaller LGE%. Histology and imaging correspond well. Impact: By non-invasively analyzing the heart's structure and function, CMR helps us evaluate the potential of using patches to treat MI and offers valuable insights for preventing ventricular aneurysms after heart attacks in clinical practice.
Authors
- Yunzhu Wu (ORCID: https://orcid.org/0000-0002-4511-762X)
- Chengbin He (ORCID: https://orcid.org/0000-0002-5435-7967)
- Jiaqi Xu (ORCID: https://orcid.org/0000-0002-4883-7358)
- Hongjie Hu (ORCID: https://orcid.org/0000-0002-9859-5860)
- Junjie Zhou (ORCID: https://orcid.org/0000-0002-8024-7059)
- Fuyan Wang (ORCID: https://orcid.org/0000-0002-6052-1321)
- Lingjie Zhang (ORCID: https://orcid.org/0000-0002-5183-465X)
- Siying Ma
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1512
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00