Predicting response to neoadjuvant chemotherapy in breast cancer by biomechanics quantified with Magnetic Resonance Elastography.
Motivation: To achieve de-escalation of surgery in breast cancer patients having complete response after primary chemotherapy, we require better accuracy than the current gold standard DCE-MRI, which has a sensitivity of 80-90% and a specificity of 37-97%. Goal(s): Investigate the diagnostic value of biomechanical imaging biomarkers quantified via MR-Elastography (MRE) for gauging complete pathological response non-invasively. Approach: Incorporate MRE into standard Breast MRI protocol for NACT patients within standard-of-care MRI protocol. Results: Biomechanical changes in conjunction with DCE MRI improved sensitivity to 94.4% and specificity to 95.7%, making this approach a promising new concept to predict complete response after NACT. Impact: Quantifying biomechanics throughout chemotherapy via MR-Elastography (MRE) in conjunction with DCE-MRI in breast cancer patients undergoing primary chemotherapy yields more accurate results in predicting complete pathological response than current international imaging gold standard methods.
Authors
- Zhane Peterson
- Keshthra Satchithananda (ORCID: https://orcid.org/0000-0001-9652-2521)
- Tony Ng (ORCID: https://orcid.org/0000-0003-3894-5619)
- Ashutosh Kothari (ORCID: https://orcid.org/0000-0001-9781-9466)
- J. David Spence (ORCID: https://orcid.org/0000-0001-7478-1098)
- Arnie Purushotham (ORCID: https://orcid.org/0000-0001-8577-9655)
- Hannah Jeffery (ORCID: https://orcid.org/0000-0002-2305-6969)
- Anne Rigg (ORCID: https://orcid.org/0000-0003-2988-157X)
- Mangesh A. Thorat (ORCID: https://orcid.org/0000-0001-8673-5320)
- Omar Darwish (ORCID: https://orcid.org/0000-0003-4747-9007)
- Georgina Bitsakou
- Anna Metafa (ORCID: https://orcid.org/0000-0001-6445-742X)
- Elina Shaari
- Ralph Sinkus (ORCID: https://orcid.org/0000-0002-6093-1654)
- Patriek Jurrius (ORCID: https://orcid.org/0000-0002-3706-023X)
- Vasileios Karydakis
- Ali Sever (ORCID: https://orcid.org/0000-0001-6955-0789)
- Aaditya Sinha (ORCID: https://orcid.org/0000-0002-8930-593X)
- K. A. Welsh (ORCID: https://orcid.org/0009-0007-6668-8791)
- Hisham Hamed
- Sarah E. Pinder (ORCID: https://orcid.org/0000-0003-4167-8910)
- Belul Shida
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4610
- Primary Topic
- Ultrasound Imaging and Elastography
- Type
- article
- Field-Weighted Citation Impact
- 0.00