Association of reduced cortical thickness with myocardial strain in patients with heart failure

Motivation: The mechanism of heart failure()-induced brain alterations is unclearGoal(s): To investigate the alterations in brain structure in patients with HF and their relationship with cardiac dysfunction and cognitive impairment. Approach: Using CAT12 to analyze intergroup differences in cortical thickness between HF patients and healthy controls, correlation analyses were performed to assess cortical thickness and cognitive impairment, cardiac dysfunctionResults: Reduced cortical thickness in patients with HF and correlation of reduced cortical thickness with cognitive impairment and cardiac dysfunctionImpact: Decreased cortical thickness in HF patients may play a mediating role between cardiac dysfunction and cogntive impairment.And our findings provide imaging evidence of brain alterations in HF patients.