Aberrant functional network connectivity of cerebellar network in methamphetamine-dependent patients: a resting-state fMRI study

Motivation: There are limited researches on functional network connectivity related to methamphetamine (MA), with existing studies predominantly focused on MA abstainers and lacking studies on the MA dependence. Goal(s): This study aims to investigate the alterations in functional connectivity within and between resting-state networks (RSNs) in MA-dependence. Approach: Using independent component analysis to acquire RSNs, calculate FCs within and between RSNs, and perform group comparison and correlation analysis. Results: The MA group presented not only decreased rs-FC within the cerebellar network, but abnormal inter-networks rs-FC, especially between the cerebellar network and multiple cerebral networks, which is also associated with the severity of psychotic symptoms. Impact: The cerebellar network of MA dependent individuals needs to be emphasized in future studies.