A cine-ASL magnetic resonance method detects microvascular dysfunction in a mouse model of heart failure with preserved ejection fraction

Motivation: Addressing the challenges in heart failure with preserved ejection fraction (HFpEF) diagnosis, the study aimed to validate cine-ASL as a precise non-invasive imaging tool. Goal(s): The study sought to explore nuanced aspects of HFpEF, enabling a better understanding of its complexities through advanced imaging techniques. Approach: Employing advanced cardiac magnetic resonance imaging with arterial spin labeling (cine-ASL), our study investigates longitudinally myocardial perfusion in a two-hit mouse HFpEF model. Results: Significant reductions in myocardial perfusion in a HFpEF-like mouse model revealed the technique's efficacy in capturing HFpEF-related changes. Impact: These findings highlight early coronary microcirculation impairment in HFpEF-like myocardium, shedding light on potential diagnostic biomarkers for HFpEF and paving the way for improved early diagnosis and understanding of the HFpEF pathophysiology.