Neurochemistry, microstructure, and perfusion in long-COVID: An interim analysis from a multisite study
Motivation: There is an urgent need to understand the biological basis of long-COVID. Goal(s): To elucidate long-term consequences of SARS-CoV-2 infection in the brain using advanced MRI. Approach: In a multisite study, we collected single-voxel MRS, diffusion MRI, pCASL and T2 FLAIR MRI, to investigate the neurochemistry, microstructure, perfusion, and white matter hyperintensities (WMH) in participants suffering from long-COVID. Results: Participants with long-COVID have long-lasting effects (that persist years after acute infection) in the neurochemistry, microstructure, and perfusion, primarily in the brainstem, midbrain and diencephalon, and their connecting tracts, without the presence of overt white matter pathology. Impact: Multi-modal advanced MRI demonstrates long-lasting effects of COVID-19 in the brain, including neurochemical and microstructural abnormalities and perfusion deficits. These insights may facilitate the treatment and care of people suffering from long-COVID.
Authors
- Sevil Yaşar (ORCID: https://orcid.org/0000-0002-5080-6534)
- Michel Toledano (ORCID: https://orcid.org/0000-0002-9046-7880)
- Lauren Pollak
- Peter B. Barker (ORCID: https://orcid.org/0000-0002-6410-7793)
- Merve Atık
- Orhun H. Kantarci (ORCID: https://orcid.org/0000-0001-7038-8133)
- Jeromy Thotland
- Katherine Gundry (ORCID: https://orcid.org/0000-0002-3333-1709)
- James M. Joers (ORCID: https://orcid.org/0000-0002-8444-2185)
- G. Kyle Harrold (ORCID: https://orcid.org/0000-0001-6166-188X)
- Tetsuo Ashizawa (ORCID: https://orcid.org/0000-0001-7180-2869)
- Burcu Zeydan (ORCID: https://orcid.org/0000-0002-2270-9868)
- Gülin Öz (ORCID: https://orcid.org/0000-0002-5769-183X)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Mehreen Nabi
- Ana Roberta Vilarouca da Silva (ORCID: https://orcid.org/0000-0001-5087-4310)
- Christof Karmonik (ORCID: https://orcid.org/0000-0002-6695-9535)
- Christophe Lenglet (ORCID: https://orcid.org/0000-0003-4646-3185)
- Lynn E. Eberly (ORCID: https://orcid.org/0000-0003-4763-330X)
- Shibani S. Mukerji (ORCID: https://orcid.org/0000-0002-5677-6954)
- Abby Metzler
- David H. Salat (ORCID: https://orcid.org/0000-0002-2246-9657)
- J Kendall
- Meher R. Juttukonda (ORCID: https://orcid.org/0000-0001-9064-3648)
- Janet C. Sherman (ORCID: https://orcid.org/0000-0001-9782-3158)
- Dinesh K. Deelchand (ORCID: https://orcid.org/0000-0003-4266-4780)
- Georgios Manousakis (ORCID: https://orcid.org/0000-0002-8309-9426)
- Xiufeng Li (ORCID: https://orcid.org/0000-0002-0764-4613)
- Young Ho Park (ORCID: https://orcid.org/0000-0002-2756-1786)
- Sana Rehman (ORCID: https://orcid.org/0000-0001-8183-1778)
- Syed Amir Gillani
- Rachel Davis
- Vanesa Flores
- Eva Ratai
- Kejal Kantarci
- Keenan Byrne
- Alfredo Lorente
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2084
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00