Multi-delay Arterial Spin Labeling Magnetic Resonance Imaging of Cerebral Blood Flow in Patients With Vertebrobasilar dolichoectasia

Motivation: Vertebrobasilar dolichoectasia (VBD) poses a risk to cerebral blood flow and can lead to ischemic strokes. Understanding its impact on blood flow and identifying predictive factors are crucial. Goal(s): This study aims to assess differences in CBF and other parameters between VBD patients and controls. We also investigate the influence of extracranial blood flow and predict PCI risk factors. Approach: 32 VBD patients and 32 controls underwent Multi-delay-ASL and Doppler ultrasound. We analyzed CBF, aCBV, ATT, and blood flow velocities. Results: VBD patients exhibited lower CBF and aCBV in both circulations and longer ATT. Bilateral occipital and cerebellar ATTs predicted PCI. Impact: This study enhances our understanding of VBD's impact on cerebral blood flow and identifies predictors of posterior circulation ischemia. It underscores the importance of maintaining extracranial blood flow, aiding in early detection and prevention of ischemic strokes in VBD patients.